Rice antioxidants: Phenolic acids, flavonoids, anthocyanins, proanthocyanidins, tocopherols, tocotrienols, y-oryzanol, and phytic acid. Obesity and obesity-related hypertension have become a global general public health burden; their incidence becoming similar with those of diabetes mellitus and chronic kidney diseases [3]. The pancreatic lipase (PL) (EC: 3.1.1.3) takes on a pivotal part in the effective digestion of lipids, as it is responsible for the hydrolysis of the bulk (50-70%) of total dietary fats [4]. It is the important enzyme that hydrolyzes triglyceride to produce glycerol and fatty acids, therefore facilitating its uptake [5]. Thus, it is widely used as an index to evaluate the potential effectiveness of natural products as anti-obesity providers [6]. Due to the vital catalytic function of PL, orlistat, currently used clinically for obesity management, has been designed to inhibit PL activity; therefore reducing the absorption of triglyceride. However, this drug like additional PL inhibitors offers some hepatic and gastrointestinal adverse effects [7,8]. The activation of the rennin-angiotensin system (RAS) has been reported as one of the possible mechanisms through which obesity could lead to hypertension and higher cardiovascular risk [3]. In fact, experimental evidence has shown that this RAS is activated in obesity; its involvement in the pathophysiology of obesity-related hypertension has also been reported [9]. In the RAS, angiotensin 1-converting enzyme (ACE) (EC: 3.4.15.1) plays a key role in the regulation of blood pressure and normal cardiovascular function. It catalyzes the conversion of angiotensin I to angiotensin II, which is known to increase the blood pressure. Hence, inhibition of ACE is an important strategy for the treatment and management of obesity-related hypertension [10,11]. Chemically synthesized ACE inhibitors including captopril, ramipril, enalapril and fosinopril, comprise a class of drugs frequently used clinically for the treatment of hypertension [12]. However, as with the PL inhibitors, these drugs have been reported to have some adverse effects such as cough, skin rashes, hypotension, and proteinuria [13,14]. Against the backdrop of the side effects associated with the synthetic inhibitors of both PL and ACE, research has shown that plant-derived inhibitors of these two enzymes have some potential for preventing or ameliorating obesity and hypertension, without noticeable side effects [15,16]. In this regard, plant polyphenolics have been reported by several studies to inhibit either one of these two enzymes (PL and ACE) or both [4,5,17,18]. The genus, (Lamiaceae), comprises 65 aromatic species, distributed in tropical and subtropical regions of the world including Africa and Asia [19]. Various species, including and leaves extract possesses anti-arthritic [22], hypoglycemic [19], anticonvulsant and anxiolytic activities [23]. On the other hand, leaves are used as anti-spasmodic, carminative, galactagogue, and stomachic in folk medicine [24]. To further explore the nutraceutical benefits of and and were collected from Erdafitinib (JNJ-42756493) a local farm settlement in Akingbile area of Moniya, Ibadan, Nigeria. The samples were botanically identified and authenticated at the herbarium of the Department of Botany, University of Ibadan, Nigeria. Subsequently, they were air-dried for 7 days and later ground finely to a particle size of 0.5 mm. The powdery samples were used for the extracts preparation. Chemicals and Reagents Methanol, formic acid, gallic acid, chlorogenic acid, caffeic acid, and ellagic acid were purchased from Merck (Darmstadt, Germany). Catechin, epicatechin, quercetin, rutin, apigenin, and luteolin; porcine PL, Hippuryl-histidyl-leucine, Rabbit lung ACE, DPPH, ABTS, and Trolox were acquired from Sigma Chemical Co. (St. Louis, MO, USA). Erdafitinib (JNJ-42756493) All other chemicals used for the analysis were of analytical grade. Preparation of Polyphenolics Extract Polyphenolics extracts of and leaves were prepared as described by Kuo and [Physique 1a and ?andb]b] revealed the presence of gallic acid (retention time – Rt = 10.19 min; peak 1), chlorogenic acid (Rt = 22.35 min; peak 3), caffeic acid (Rt = 26.97 min; peak 4), epicatechin (Rt = 37.41 min; peak 6), rutin (Rt = 43.86 min; peak 7), quercitrin (Rt = 48.13 min; peak 8), quercetin Erdafitinib (JNJ-42756493) (Rt = 52.01 min; peak 9), and kaempferol (Rt = 57.69 min; peak 10). In addition to these, catechin COL27A1 (Rt = 16.07 min; peak 2), ellagic acid (Rt = 29.83 min; peak 5), and luteolin.