All the authors reviewed the final version of the manuscript and agreed to its submission.. system (GIS) mapping technology helped in tacking the quick diagnosis and tracking viral contamination in a short period. In the same way, artificial intelligence (AI), combinatorial chemistry, and deep learning methods help to find novel therapeutics in less time and wide applicability in biomedical research. National Institute of Allergy and Infectious Diseases (NIAID) has started the clinical trials of investigation COVID-19 vaccine. Therefore, we can expect vaccines to be available for this fatal disease in the coming few months. of the genus pathway. This led to the further implication of this virus transmission in humans posing severe public health risks and modeled through computer virus spike protein [37]. Deng and Peng (2020) pointed out the guidelines for the treatment of COVID-19 should be followed for general and specialized procedures along with the responsibility PRKCB of Methazolastone different businesses in the outbreak. This led to entirely or partially lock-down and of approximately 60 million affected people and local transportation in Beijing and Shanghai. Comparable, instances had occurred in other countries by which human contact restriction, contact with wild animals, airport screening, creation of isolation centers, cancellation of flights, new isolation wards and new medical units constructed, etc. Methazolastone Instead of person- to- person respiratory and body contact, the fecal-oral transmission also acts as one of the routes of contamination of this fatal virus [38]. The case of tertiary transmission of the case of an indexed individual in Korea through the use of Lopinavir/Ritonavir for COVID-19 treatment, detection thorough RT-PCR [25] and other clinical laboratory features decided through imaging method [39]. Open in a separate window Physique 2. Phylogenetic analysis of full-length genomes of 2019-nCoV and representative viruses of the genus Betacornaviridae (reproduced with permission Methazolastone from publisher from Reference, Lu et al. 2020, Lancet. 2020 Feb 22;395(10224):565-574) [4]. Open in a separate window Physique 3. Phylogenetic analysis and homology modeling of the receptor-binding domain name of the SARS-CoV-2, SARS-CoV, and MERS-CoV. (A) Phylogenetic analysis of the receptor-binding domain name from numerous betacoronaviruses. The star highlights SARS-CoV-2 and the question marks means that the receptor used by the viruses remains unknown. Structural comparison of the receptor-binding domain name of SARS-CoV. (B), 2019-nCoV (C), and MERS-CoV(D) binding to their own receptors. Core subdomains are magenta, and the external subdomains of SARS-CoV, SARS-CoV-2, and MERS 9CoV are orange, dark blue, and green, respectively. Variable residues between SARS-CoV and 2019-nCoV in the receptor-binding site are highlighted as sticks. CoV =. 2019-nCoV = 2019 novel. SARS-CoV-2 = severe acute respiratory syndrome. MERS = Middle East respiratory syndrome (Reproduced with permission from publisher from reference, Lu et al. 2020, Lancet. 2020 Feb 22;395(10224):565-574) [4]. 4.?Precautions to fight against coronavirus Recent transmission of Ebola computer virus, Nipah computer virus, MERS, and Crimean-Congo hemorrhagic fever, have indicated the risk of nosocomial transmission of emerging infections in healthcare settings [20]. SARS and MERScan persist to inanimate surfaces (2C10 days) and can be inactivated by biocidal brokers [40]. However, there is no specific therapy available for SARS-CoV-2 initial containment and prevention of spread [40]. Therefore, COVID-19 is usually a rapidly evolving situation and new, even stable for hours on the surfaces similar to other SARS computer virus [41]. As per the rapid advance guidelines for diagnosis and treatment of SARS-CoV-2 infected (standard version), these guidelines are first to hospital staff and medical professionals, community residents, and public health persons and experts as well [42]. For the precaution point of view, the specific guidelines to be followed, available from (www.coronavirusgov and http://who.int, Who also guidelines). We need to watch for symptoms to appear in the patient with travel history or human-to-human contact in the past few days. The illnesses vary from moderate to severe illness symptoms, and even death occurs among the COVID-19 in severe cases and the standard guidelines for screening of COVID-19 should be followed (www.coronavirus.gov). The COVID-19.