Labeling of lipids in cultures of glioma progenitors expressing IDH1R132H was minimally influenced by introduction of human GLUD1. demonstrate that exerts a growth-inhibitory effect that is paralleled by deficiency in metabolic flux from glucose and glutamine to lipids. Examining human gliomas, we find that glutamate dehydrogenase 1 (GLUD1) and GLUD2 are overexpressed in mutation on…